Head and Neck ImagingCogan's syndrome
(David Glendenning Cogan, 1908 -1993, American ophthalmologist), nonsyphilitic
interstitial keratitis characterized by an abrupt onset with
vertigo and
tinnitus followed by deafness due to autoimmune
labyrinthitis . About 50% of patients have an associated systemic disease, most commonly polyarteritis nodosa. It is also known as oculovestibulo-auditory syndrome.
CT and
MRI may show calcific obliteration and soft-tissue obliteration of the intralabyrinthine fluid spaces;
MRI may reveal hyperintensity inside the membranous labyrinth on T1-weighted images and enhancement on gadolinium-enhanced images, probably representing leakage through the abnormal labyrinthine membrane caused by active disease.
RH