Cardiovascular Imaging

Cardiomyopathy, infiltrative

disease of the myocardium caused by infiltration of abnormal cells or substances. Infiltrative cardiomyopathies produce pathophysiological manifestations of restrictive cardiomyopathy or dilated cardiomyopathy or a combination of the two. The cardiomyopathy is frequently a component of a systemic disease such as amyloidosis, sarcoidosis, haemochromatosis, glycogenosis and others.

The features displayed by imaging studies are as described for dilated cardiomyopathy and restrictive cardiomyopathy. Identifying characteristics for specific infiltrative processes may be shown by imaging studies. Amyloidosis is identified by high reflectance of the myocardium on echocardiography and altered T2 relaxation times on MRI (see cardiomyopathy amyloid). Myocardial signal intensity may be substantially lowered, especially on gradient echo images in haemochromatosis. High-signal intensity foci in the myocardium on T2-weighted spin echo images caused by granulomas have been reported in sarcoidosis.

CBH