Sjogren's syndrome

(Henrik Samuel Conrad Sjogren, 1899 - 1986, Swedish ophthalmologist), a myeloproliferative disorder with a classic triad of signs consisting of keratoconjunctivitis sicca, xerostomia and rheumatoid arthritis. In some patients, however, only two of these findings are present.

Joint involvement resembles that occurring in rheumatoid arthritis, with subcutaneous nodules, soft tissue swelling, periarticular osteoporosis, marginal erosions, joint space narrowing and intra-articular cystic lesions. Other manifestations include Raynauds phenomenon, splenomegaly, leukopenia, infections, vasculitis, peripheral neuropathy, glomerulonephritis and purpura.

DR