Musculoskeletal ImagingMalignant degeneration
the transformation of a
benign lesion into a
malignant one. This sequence may occur in numerous conditions, including
fibrous dysplasia,
giant cell tumour,
hereditary multiple exostoses (
Fig.1),
Maffuccis syndrome,
enchondromatosis,
osteonecrosis,
chondromyxoid fibroma,
enchondroma,
Pagets disease,
neurofibromatosis,
osteoblastoma, simple
bone cysts and
exostosis.
DR/RB
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a. CT scout view demonstrates a large soft tissue mass containing chondroid calcifications in the right thigh. Also note the presence of osteochondromas arising from the femora in this patient with multiple hereditary exostoses.
b, c. Axial CT scan (b) and axial T2-weighted MR image (c) demonstrate the chondrosarcoma occurring secondary to malignant degeneration of an osteochondroma.
(Courtesy of Douglas Goodwin, MD, Lebanon, NH)
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Malignant degeneration, Fig.1 (a) | | Malignant degeneration, Fig.1 (b) | | Malignant degeneration, Fig.1 (c) |