The head and neckThyroid and parathyroid glands
Technique
Nuclear medicine studies using iodine isotopes is used to study the size, location and function of the thyroid gland, as well as, demonstrate intraglandular lesions. Ultrasound has higher diagnostic yield than computed tomography to demonstrate and characterize small adenomas in both the thyroid and the parathyroid glands. Ultrasound can also differentiate between cyst and solid tumors seen as cold nodules on isotope studies. Intrathoracic extension of thyroid tumors or goiter is better demonstrated by computed tomography or magnetic resonance imaging.
Anatomy
Because of its high iodine content the normal thyroid gland can be seen as hyperdense tissue easily separated from the surrounding structures even without contrast enhancement. The triangle shaped lobes on both sides of the trachea are connected anteriorly by the isthmus. The internal jugular veins and the common carotid arteries are found adjacent to the thyroid lobes (Fig 25 d). The four parathyroid glands can normally not be visualized by cross sectional imaging. The glands are located in association with each pole of the thyroid lobes in the angle between the common carotid artery and the oesophagus.
Pathology
It is not possible to differentiate between benign thyroid adenomas and malignant nodules with any imaging method. Ultrasound and nuclear medicine studies are still the most useful to evaluate an enlarged thyroid gland. In hyperparathyroidism ultrasound is the primary method to localise a parathyroid expansion. If the ultrasound and radionuclide examination of the neck is negative computed tomography or magnetic resonance imaging can be used to assess for adenomas in the upper mediastinum. In previously operated cases with persistent or recurring hyperparathyroidism ultrasound, radionuclide and cross sectional imaging can be supplemented by selective venous sampling and digital subtraction angiography. Two studies should be positive to confidently identify recurrent adenoma or hyperplasia unless one positive study appears absolutely definitive.
Sven G. Larsson and Anthony A. Mancuso