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Chemotoxicity

The part of the toxic effect of contrast media that is related to the chemical properties of the molecule. A high chemotoxicity in contrast media is associated with a high degree of protein binding, a high tendency to release histamine or to inhibit biological processes like enzymes. The inhibition of clotting  by ionic contrast media is a consequence of high chemotoxicity. Contrast media with high chemotoxicity will have higher general toxicity (low LD50) regardless of osmolality. Adverse events during X-ray examinations typically associated with chemotoxicity include nausea and vomiting.  

 

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