Osmotoxicity
The part of the toxic effect of the contrast medium that is related to osmolality. High-osmolar contrast media have a strong osmotoxicity, low-osmolar contrast media only very limited, and isosmolar products no osmotoxicity at all. Adverse effects attributed to osmotoxicity are feeling of warmth during injection, hypotension due to reduced resistance in the peripheral circulation, hypertension due to increased plasma volume, stiffening of erythrocytes affecting blood pressure and lung function and many more.
GE Healthcare Glossary