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LD50

LD50 is the abbreviation of "lethal dose in 50%", i.e. the dose of a substance that will kill 50% of an animal population. The higher the LD50 of a substance, the more is needed to kill an animal, which again means a higher safety margin. For most new drugs and contrast media the safety margin is established in an early phase of development by means of LD50. Usually LD50 is measured in small populations of small animals like mice or rats. 

 

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